Anti-HIV Drug-Combination Nanoparticles Enhance Plasma Drug Exposure Duration as Well as Triple-Drug Combination Levels in Cells Within Lymph Nodes and Blood in Primates
نویسندگان
چکیده
منابع مشابه
Long-acting combination anti-HIV drug suspension enhances and sustains higher drug levels in lymph node cells than in blood cells and plasma
OBJECTIVE The aim of the present study was to determine whether a combination of anti-HIV drugs - tenofovir (TFV), lopinavir (LPV) and ritonavir (RTV) - in a lipid-stabilized nanosuspension (called TLC-ART101) could enhance and sustain intracellular drug levels and exposures in lymph node and blood cells above those in plasma. DESIGN Four macaques were given a single dose of TLC-ART101 subcut...
متن کاملTreatment of Severe Alopecia Areata Using Methotrexate as an Adjunctive Drug in Combination with Intravenous and Oral Corticosteroid
Background: Alopecia areata is one of the most common human autoimmune disorders and its severe types are refractory to all conventional therapies. Corticosteroids have been used in severe alopecia areata since 1950s but there is concern over complications caused by high doses of corticosteroids. Methotrexate has been used as an adjunctive therapy in some autoimmune disorders and has been propo...
متن کاملDrug combination therapy increases successful drug repositioning.
Repositioning of approved drugs has recently gained new momentum for rapid identification and development of new therapeutics for diseases that lack effective drug treatment. Reported repurposing screens have increased dramatically in number in the past five years. However, many newly identified compounds have low potency; this limits their immediate clinical applications because the known, tol...
متن کاملP 101: Ginger and Honey Mixture as an Anti-Inflammatory Drug in Neuroinflammation:Alzheimer Disease
Nowadays, many people prefer to use herbal remedies instead of chemical treatments, because of a fewer side effects. It seems that herbal drugs can be useful to neuroinflammation diseases like Alzheimer. Alzheimer Disease (AD) is caused by the oxidative stress and inflammatory compounds such as cytokine and beta-amyloid. It causes learning problems due to damage in cells in the hippocampus area...
متن کاملDrug Combination Analysis
Drug-combination analysis is discussed and demonstrated. Suppose we have a set of drugs (or other treatments which we misclassify as “drugs” for the purpose of our analysis.) These drugs are supposed to be treatments for some disease, e.g., HIV infection. Our goal is to assess whether, and to what extent, treatment with a particular combination of these drugs is more or less effective than some...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: AIDS Research and Human Retroviruses
سال: 2015
ISSN: 0889-2229,1931-8405
DOI: 10.1089/aid.2014.0210